Table 1:
List of clinical trials (completed/ongoing) on the effect of polyphenolic on autoimmune diseases
| S.No. | Plant/polyphenols | Autoimmune disorders | Study design (age, sex, doses) | Status | Reference (clinical trial number) |
|---|---|---|---|---|---|
| 1 | MEMOREX 60 mg BID (Gingko biloba) and narrow band UVB | Vitiligo | Randomized double-bling placebo controlled trial (160 participants, 12–65 years) | RECRUITING | NCT01006421 |
| 2 | 60 mg Ginkgo biloba BID for 12 weeks | Vitiligo vulgaris | Non-randomized single group assignment (12 participants, 12–18 years) | completed | NCT00907062 |
| 3 | 5 aminosalicylicacid +curcumin (50–100 mg BID) | ULCERATIV E COLITIS | Randomized parallel assignment (50 participants, 18–70 years) | RECRUITING | NCT02683759 |
| 4 | 5 aminosalicylicacid +curcumin (500 mg BID) | ULCERATIV E COLITIS | Randomized parallel assignment (50 participants, 18–70 years) | completed | NCT01320436 |
| 5 | Aloe barbadnsis (200 ml per day for three months) | Inflammation in patients with mild ulcerative colitis | Randomized parallel assignment (60 participants, 18–59 years) | recruiting | NCT01783119 |
| 6 | CURCUMIN (1–2 g BID) | Pediatric ulcerative colitis | Randomized double-blind parallel assignment (60 participants, 6–18 years) | Not yet recruiting | NCT02277223 |
| 7 | Curcumin (3g per day) | ULCERATIVE COLITIS IN REMISSION | Randomized double-blind parallel assignment (172 participants, 18 years and older) | RECRUITING | NCT03122613 |
| 8 | Quercetin (1000 mg per day) | Sarcoidosis | Randomized double-blind parallel assignment (18 participants) | Completed (reduced markers of oxidative stress and inflammati on in sarcoidosis patients) | NCT00402623 |
| 9 | Ashwagandha (3 ml for 5 days) | Inflammation, cancer and autoimmune disease | Non-randomized single group assignment (25 participants) | Completed | NCT00817752 |
| 10 | Red Yeast Rice and Tea | Rheumatoid Arthritis | Randomized parallel assignment (120 participants, 18–75 years) | Recruiting | NCT02257047 |
| 11 | Resveratrol (80 mg per day for 2 months) | Spastic Paraplegia | Randomized crossover assignment (12 participants, 18 years and older) | Completed | NCT02314208 |
| 12 | High Flavanol Cocoa drink (450 mg cocoa flavanols BID for 7 days) | Peripheral and cerebral blood flow in diabetes type −2 | Randomized crossover assignment (18 participants, 35–70 years) | Completed | NCT01654172 |
| 13 | Green tea extract (capsule containing 160 mg teavigo (94% epigallocatechin-3-gallate) DAILY FOR 3 MONTHS | Multiple sclerosis | Randomized crossover assignment (20 participants, 20–60 years) | completed | NCT01417312 |
| 14 | Green Tea (1000 mg aqueous green tea extract per day for 3 months) | Lupus | Randomized double-blind parallel assignment (68 participants, 15 years and older) | Completed | NCT02875691 |
| 15 | Antioxidant cocktail (vitamin C, E, alpha lipoic acid) and Resveratrol (270mg) | Type 1 diabetes | Randomized double-blind parallel assignment (198 participants, 18–40 years) | Recruiting | NCT03436992 |
| 16 | Curcumin | Pelvic inflammatory disease, Endometritis, wound infection | Randomized parallel assignment (180 participants, 18–52 years) | NCT03016039 | |
| 17 | Liquorice (150 g glycyrrhizinic acid) and Grapefruit juice (200 ml three times a day) | Addison Disease | Randomized crossover assignment (17 participants, 18–80 years) | Completed | NCT01271296 |
| 18 | Epigallocatechinga llate (600mg per day) | Multiple Sclerosis | Randomized parallel assignment (60 participants, 18–52 years) | Recruiting |
NCT03740295 |
| 19 | Migh Tea flow (green tea, jaborandi extract, xylitol) 4–6 times daily for 8 weeks | Sjogren syndrome | Randomized double-blind parallel assignment (60 participants, 18–75 years) | Completed |
NCT01647737 |
(NCT: numbers refer to the source of www.clinicalTrails.gov).