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. Author manuscript; available in PMC: 2019 Jun 21.
Published in final edited form as: Arthritis Rheum. 2013 Feb 1;65(2):481–491. doi: 10.1002/art.37738

Figure 3.

Figure 3

Impaired interleukin-10 (IL-10) expression in TNF-costimulated SSc lymphocytes. A, Baseline secretion of IL-10 in CD3/CD28-activated lymphocytes from SSc patients and healthy controls (n = 8 per group). IL-10 levels were significantly decreased in lymphocytes from SSc patients. B, Effects of costimulation with TNFRs or soluble TNF (sTNF) on IL-10 expression. TNFRII-mediated costimulation increased IL-10 expression in lymphocytes from controls, but not in lymphocytes from SSc patients. Values are the mean ± SEM. * = P < 0.05. See Figure 1 for other definitions.