Table 1. Serial plasma troponin I concentrations in a pedigree with Danon disease.

Patient and Age	c864 + 4A > G Mutation Status	Clinical Severity	BMI	Mean troponin I	Range	Standard Deviation
Case A. Eldest brother Age 21 5 years troponins	Hemizygous	Deceased Severe	37	4.6	2.0–6.3	1.5
Case B, Middle Son Aged 23 7 years of troponins	Hemizygous	Deceased Severe	28	8.7	0.8–40	11.0
Case C, Youngest Son Age 21 4 years of troponins	Hemizygous	Severe	37	7.0	3.8–18.4	6.3
Case D, Their mother Age 57 7 years of troponins	Heterozygous	Moderate	41.6	0.30	0.15–0.55	0.12
Case G, Their grandmother Age 76 1 year of troponins	Heterozygous	Moderate	26.8	0.13	0.1–0.15	0.03
Case F, Their Aunt Age 62 6 years of troponins	Heterozygous	Mild/Moderate	33.1	0.14	0.07–0.18	0.05
Case E, Their cousin Age 31 6 years of troponins	Hemizygous	Minimal	25.4	0.07	N/A	0.05

Note the higher body mass index values seen in the more severely affected children.

Reference range for healthy adults: 0–0.1 μg/L.