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. Author manuscript; available in PMC: 2019 Jun 21.
Published in final edited form as: Nature. 2017 Jun 14;546(7660):662–666. doi: 10.1038/nature22795

Figure 4. Arginase 2+ fetal cDC regulate TNF-α production.

Figure 4

a, Cytokine production by adult T cells after 6 days co-culture with fetal or adult cDC2 (n=5). b, c Expression of arginase-2 gene (b) and protein (c) in cDC2. d, Splenocyte T cell TNF-α production. e, f TNF-α production (red) of stimulated adult T cells, after overnight culture in the absence (Day 0) or presence of cDC2 (Day 6 of co-culture), with or without additional supplementation of L-arginine or arginase inhibitors (ABH or BEC). e, Representative dot plots. f, Cumulative data. g, TNF-α production from stimulated fetal T cells under indicated culture conditions. Data shown as mean±s.e.m. *p<0.05, **p<0.01, ***P<0.001, Mann-Whitney test. Each data point in the scatter plots represents an individual experiment.