Table 2.
Genotypic distribution and allelic frequencies of genetic markers in the phase I.
| CHR | SNP | Gene | A1 | A2 | Genotipic distribution in HCV-infected group I (A1A1/A1A2/A2A2) | Genotipic distribution in control group I (A1A1/A1A2/A2A2) | A1 frequency in HCV-infected group I (%) | A1 frequency in control group I (%) | P† |
|---|---|---|---|---|---|---|---|---|---|
| 1 | rs6687605 | LDLRAP1 | A | G | 81/203/117 | 202/403/196 | 45.51 | 50.37 | 0.024 |
| 1 | rs4075184 | LDLRAP1 | A | G | 77/204/123 | 202/403/196 | 44.30 | 50.37 | 0.004 |
| 1 | rs11563 | LDLRAP1 | A | C | 77/205/121 | 202/403/196 | 44.54 | 50.37 | 0.006 |
| 1 | rs7552841 | PCSK9 | A | G | 78/197/127 | 143/389/265 | 43.90 | 42.34 | 0.466 |
| 1 | rs603247 | PCSK9 | G | A | 9/111/282 | 19/231/547 | 16.04 | 16.87 | 0.605 |
| 5 | rs12654264 | HMGCR | A | T | 60/183/161 | 90/371/306 | 37.50 | 35.91 | 0.449 |
| 8 | rs328 | LPL | G | C | 6/79/319 | 13/176/609 | 11.26 | 12.65 | 0.323 |
| 9 | rs7032549 | VDLDLR | G | A | 91/210/103 | 157/413/231 | 48.51 | 45.38 | 0.145 |
| 9 | rs10812379 | VDLDLR | G | A | 38/179/184 | 81/348/361 | 31.79 | 32.27 | 0.811 |
CHR, Chromosome; A1, Allele 1; A2, Allele 2; LDLRAP1, Low density lipoprotein receptor adaptor protein 1; PCSK9, Protein convertase subtilisin/kexin-type 9; HMGCR, 3-Hydroxi-3-methylgluraryl-CoA reductase; LPL, Lipoprotein lipase; VDLDLR, very low density lipoprotein receptor.
†Calculated by PLINK software using standard case/control allelic association analysis.