. 2019 Jun 21;10:2752. doi: 10.1038/s41467-019-10711-1

Table 3.

Comparison of data obtained for PS 18:0/18:1 with those obtained for other PS species

Methods used to generate data	Conclusions
MS analyses of cells	PS 18:0/18:1 is by far the most abundant PS species in most cell lines (see Table 1).
MS analyses of exosomes	PS 18:0/18:1 constitute ~40% of total PS species in exosomes released from PC-3 cells and could occupy ~80% of the area of the inner leaflet covered by the very-long-chain sphingolipids in the outer leaflet¹¹.
Molecular dynamic simulation studies of the interdigitation between PS and sphingolipids	PS 18:0/18:1 was the only species giving increased interdigitation with SM d18:1/24:0 in the presence of cholesterol, and interdigitation was stronger with PS 18:0/18:1 than with PS 16:0/18:1⁵².
Shielding cholesterol from cholesterol oxidase	PS 18:0/18:1 better than PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2⁵⁷.
Clustering with cholesterol in liposomes	PS 18:0/18:1 better than PS 16:0/18:1, PS 18:1/18:1 and PS 16:0/18:2⁵⁷.
Clustering of GPI-AP	PS 18:0/18:1 similar to PS 18:0/18:0; better than PS 18:1/18:1 and PS 12:0/12:0⁶³.