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. 2019 Jun 21;9:9022. doi: 10.1038/s41598-019-45440-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-PfMSP2/8 IgG exhibits enhanced functionality in the opsonophagocytosis assay as compared to anti-PfMSP2. (A,B) The ability of purified (A) PfMSP2 IgG or (B) PfMSP2/8 IgG to enhance phagocytosis of homologous P. falciparum merozoites was measured by OPA at high (0.25 mg/ml, black) and low (0.1 mg/ml, grey) concentrations. (C,D) Parallel assays with (C) PfMSP2 IgG and (D) PfMSP2/8 IgG were performed on heterologous merozoites. Phagocytosis was tested in triplicate and quantified as the percent fluorescent THP-1 following co-incubation with opsonized merozoites (% phagocytosis, mean ± SD). Concentration-matched adjuvant control-opsonized samples were subtracted as background. For statistical analysis, data from individual animals within an immunization group were averaged and compared. Asterisk indicates significance (Mann-Whitney U test, p < 0.05).