Table 1.
Growth and histology
| H1299 | A549 | All tumors | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-co-trans-plantation | Co-trans-plantation | p value | Non-co-trans-plantation | Co-trans-plantation | p value | Non-co-trans-plantation | Co-trans-plantation | p value | ||
| In vivo | ||||||||||
| Growth duration | Days | 49.00 (20) | 18.0 (11) | < 0.001 | 45.0 (10) | 23.5 (15) | < 0.001 | 45.9 (7) | 22.0 (12) | < 0.001 |
| In vitro | ||||||||||
| Beads | Number/FOV | 1.10 (0.28) | 1.3 (0.17) | 0.009 | 1.1 (0.22) | 1.3 (0.23) | 0.032 | 1.1 (0.25) | 1.3 (0.22) | 0.001 |
| MVD | Number/mm2 | 89.7 (65.49) | 203.1 (185.49) | 0.036 | 114.6 (81.98) | 153.4 (112.75) | 0.018 | 101.8 (63.3) | 171.4 (120) | 0.002 |
FOV field of view, MVD microvessel density
Tumor growth duration till endpoint and in vitro data derived from histology and immunohistology. Measurements were done as soon the tumors had reached a maximum diameter of 20 mm or after 48 days of growth, depending on which criterion was reached first. First and second column show results separated for both cell lines, third column show results for tumor cell lines merged together. Median (interquartile range)