Table 2.
Study results [18F]FDG-PET and CE-CT
| H1299 | A549 | All tumors | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-co-trans-plantation | Co-trans-plantation | p value | Non-co-trans-plantation | Co-trans-plantation | p value | Non-co-trans-plantation | Co-trans-plantation | p value | ||
| CE-CT | ||||||||||
| Tumor volume | cm3 | 1.94 (4.06) | 6.98 (7.07) | 0.17 (0.25) | 6.95 (5.94) | 0.28 (2.08) | 6.98 (5.87) | |||
| Vital volume | cm3 | 1.57 (3.10) | 5.03 (4.73) | 0.15 (0.22) | 5.39 (3.93) | 0.25 (1.60) | 5.3 (4.62) | |||
| Relative vital volume | % | 86.61 (13.15) | 74.53 (7.57) | 0.036 | 85.71 (6.93) | 80.65 (11.35) | 0.008 | 85.71 (8.36) | 77.73 (13.84) | < 0.001 |
| CE in whole tumor | % | 196.76 (55.13) | 269.92 (55.61) | 0.004 | 204.83 (45.80) | 270.20 (56.03) | < 0.001 | 201.48 (46.31) | 270.20 (50.20) | < 0.001 |
| CE in vital tumor | % | 215.42 (87.58) | 366.87 (65.43) | < 0.001 | 217.38 (45.60) | 336.54 (69.97) | < 0.001 | 217.07 (56.05) | 340.55 (78.53) | < 0.001 |
| Mean HU in vital tumor | HU | 104.50 (25) | 125.50 (19) | 0.003 | 112.50 (15) | 116.50 (12) | 0.581 | 110.50 (16) | 119.50 (15) | 0.001 |
| 18F-FDG-PET | ||||||||||
| Number of rats | N | 10 | 18 | 21 | 18 | 31 | 36 | |||
| SUVmax | 1.19 (1.41) | 2.43 (0.71) | 0.003 | 1.04 (0.60) | 3.16 (1.23) | < 0.001 | 1.14 (0.82) | 2.76 (1.01) | < 0.001 | |
| SUVmean | 1.16 (0.84) | 1.80 (0.36) | 0.011 | 1.04 (0.60) | 2.04 (0.82) | 0.001 | 1.11 (0.70) | 1.89 (0.57) | < 0.001 | |
| SUVmin | 1.13 (0.58) | 1.41 (0.41) | 0.093 | 1.04 (0.54) | 1.45 (0.58) | 0.035 | 1.05 (0.56) | 1.44 (0.47) | 0.003 | |
| Metabolic active volume (thresh.A) | cm3 | 0.18 (0.95) | 1.54 (3.92) | 0.002 | 0.01 (0.00) | 2.66 (3.75) | < 0.001 | 0.01 (0.20) | 2.06 (3.70) | < 0.001 |
| Relative met. Act. volume (thresh.A) | % | 13.39 (19.54) | 26.75 (21.62) | 0.188 | 6.25 (6.37) | 38.83 (31.81) | < 0.001 | 7.14 (11.86) | 29.72 (30.30) | < 0.001 |
| Metabolic active volume (thresh.B) | cm3 | 1.47 (2.06) | 2.54 (1.14) | 0.004 | 0.32 (0.20) | 2.29 (2.19) | 0.001 | 0.38 (1.33) | 2.42 (1.32) | < 0.001 |
| Relative met. Act. volume (thresh.B) | % | 95.29 (120.29) | 35.13 (16.62) | 0.001 | 128.57 (109.85) | 31.52 (14.15) | < 0.001 | 126.32 (115.56) | 33.83 (15.01) | < 0.001 |
| Metabolic active volume (thresh.C) | cm3 | 2.14 (3.51) | 6.84 (4.31) | < 0.001 | 0.1 (0.37) | 6.69 (5.28) | < 0.001 | 0.26 (2.60) | 6.79 (4.28) | < 0.001 |
| Relative met. Act. volume (thresh.C) | % | 93.64 (81.19) | 81.83 (23.58) | 0.833 | 51.35 (90.29) | 87.43 (22.91) | 0.111 | 62.5 (90.06) | 86.23 (22.66) | 0.196 |
HU Hounsfield Unit, CE-CT contrast-enhanced computed tomography, [18F]FDG-PET F-18-fluorodeoxyglucose positron emission tomography, threshold A 50% of brain SUVmean, threshold B 50% of tumor SUVmaximum, threshold C 1.5 x muscle SUVmean
Study results in overview. First and second column show results separated for both cell lines, third column show results for tumor cell lines merged together. Median (interquartile range)