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. 2019 Jun 21;9:9005. doi: 10.1038/s41598-019-45339-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nefopam treatment increases osteogenesis during fracture healing in old mice. (A) Representative micro-CT images of healing tibia fractures 21 days after fracture was generated. (B) Graphical representation of relative density or bone volume/total volume (BV/TV) in %. Each data point is shown as well as means and 95% confidence intervals. An asterisk over a data point indicates a significance p < 0.05 compared to control, comparison using ANOVA. (C) Representative histologic images from the tibia of an old mouse 21 days after fracture. (D) Graphical representation of percent fibrosis, cartilage, or bone. Each data point is shown as well as means and 95% confidence intervals. An asterisk over a data point indicates a significance p < 0.05 compared to controls, comparison using Kruskal-Wallis.