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. 2019 Jun 21;9:9060. doi: 10.1038/s41598-019-45515-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Motif enrichment and co-occurrence in prosensory-specific open chromatin regions of the embryonic cochlear duct. (a) Shows the motif enrichment as -log10 of the p-value in the subset of replicated peaks detected only in Sox2-EGFP^high+ cells from E12-16 cochlear duct (i.e., not detected in Sox2-EGFP- cells or other ENCODE datasets examined). (b) Plots quantitative differences in enrichment of representative motifs as the frequency of motifs relative to peak center. (c) Plots clustered matrix of the ratio of the observed frequency of co-occurrence of each combination of enriched motifs in the prosensory-specific peaks relative to the expected frequency of co-occurrence.