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. 2019 Jun 21;9:9060. doi: 10.1038/s41598-019-45515-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Developmentally-dynamic open chromatin in Sox2-EGFP^high+ cells of the embryonic cochlear duct. (a) Shows examples of developmentally dynamic ATAC-seq peaks (gold) in Sox2-EGFP^high+ cells of the E12-16 cochlear duct at the indicated loci. (b) Shows the fold difference relative to the normalized read counts for ATAC-seq peaks determined to be significantly increased (red), significantly decreased (blue) or unchanged (grey) in Sox2-EGFP^high+ cells from E16 cochlear duct versus those from E12 cochlear duct. (c) Shows the cumulative fold differences (i.e. the sum of the fold differences of all peaks nearest to each gene) in accessibility of each gene in Sox2-EGFP^high+ cells from E16 cochlear duct versus those from E12 cochlear duct. (d) Shows the numbers of differentially accessible peaks detected in Sox2-EGFP^high+ cells at the indicated stages. Note that most significant changes were detected in the E12-14.5 window. (e) Shows differential motif enrichment in peaks increasing in accessibility in E12-16 Sox2-EGFP^high+ cells from the cochlear duct relative to those decreasing in accessibility. (f) Plots normalized reads in the differentially accessible regions. (g) Plots the frequency of differentially enriched motifs relative to peak center.