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. 2019 Jun 21;9:9013. doi: 10.1038/s41598-019-45247-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transplantation of Zfp488-ZsGreen1-hNSCs and control ZsGreen1-hNSCs in the corpus callosum (CC) of mice near a demyelinating lesion for in vivo differentiation. (A) Schematic diagram of the NSC injection site and lysolecithin injection site in the CC. Transplanted (ZsGreen1 reporter) cells in both groups were mainly distributed along the corpus callosum (low power image, B,C). A single dose of lysolecithin resulted in focal demyelination at the injection site as indicated by a loss in MBP staining (D,G). Both Zfp488-ZsGreen1-hNSCs and control ZsGreen1-hNSCs migrated towards the lesion site (E,H respectively). The transplanted human NSCs were also identified by an antibody specifically against human nestin (F,I). A small fraction of human nestin-positive cells were detected in the SVZ from both groups, indicating possible homing of hNSCs (F1-F2). The scale is 50 μM.