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. 2019 May 11;116(12):2314–2330. doi: 10.1016/j.bpj.2019.05.008

Figure 1.

Figure 1

Homology model of the Tiam2 WT PDZ domain and location of the four residues mutated in this study. (A) A space-filled representation of the Tiam2 WT PDZ homology model is shown. The homology model was created using the SWISS-MODEL server (28) and the Tiam1 WT PDZ structure (PDB: 4GVC) as a template. Mutated residues are labeled and colored in red. The S0 and S-2 specificity pockets are colored yellow. (B) Shown is the amino acid sequence alignment of human Tiam1, mouse Tiam2, and the mouse Tiam2 quadruple mutant (QM) PDZ domains. The secondary structure elements are indicated by rectangles (α-helix) and arrows (β-strand). The residues highlighted in (A) are boxed and labeled. Tiam1 and Tiam2 sequence numbering is indicated at above and below of the sequence, respectively. To see this figure in color, go online.