Table 2. Potency of antipseudomonal agents in the presence of various phenotypic resistance profiles.
Phenotype profile | % susceptibility | |||||||
---|---|---|---|---|---|---|---|---|
N [%] | ATM | C/T | FEP | CAZ | IPM | MEM | TZP | |
NS to ATM | 410 [34] | – | 88 | 44 | 49 | 46 | 45 | 35 |
NS to C/T | 55 [5] | 11 | – | 9 | 7 | 25 | 22 | 15 |
NS to CAZ | 267 [22] | 21 | 81 | 20 | – | 39 | 41 | 14 |
NS to FEP | 287 [24] | 20 | 83 | – | 25 | 38 | 35 | 19 |
NS to IPM | 392 [32] | 44 | 90 | 54 | 59 | – | 27 | 49 |
NS to MEM | 316 [26] | 28 | 86 | 41 | 50 | 10 | – | 36 |
NS to TZP | 322 [27] | 17 | 85 | 28 | 29 | 39 | 38 | - |
NS to carbapenemsa | 432 [36] | 41 | 89 | 54 | 60 | 7 | 25 | 48 |
MDR | 153 [13] | 12 | 74 | 6 | 10 | 5 | 6 | 8 |
NS to 1 or more agentb | 648 [54] | 37 | 92 | 56 | 59 | 40 | 51 | 50 |
NS to all agentsc | 118 [10] | – | 75 | – | – | – | – | – |
Aztreonam (ATM), ceftolozane/tazobactam (C/T), cefepime (FEP), ceftazidime (CAZ), imipenem (IPM), meropenem (MEM) and piperacillin/tazobactam (TZP) against P. aeruginosa. a, carbapenem non-susceptibility defined as non-susceptible to IPM or MEM with MIC of >2 mg/L; b, antipseudomonal agents tested in this study (ATM, C/T, FEP, CAZ, IPM, MEM, and TZP); c, antipseudomonal agents tested in this study other than the compound of interest (ATM, FEP, CAZ, IPM, MEM, and TZP). MDR, multidrug resistant; MIC, minimum inhibitory concentration; NS, non-susceptible.