Figure 1.

circRNA expression profiles in effective and ineffective groups. (A) Unsupervised hierarchical clustering is showing distinct circRNA expression profiles among the 14 samples (light blue: the ineffective group; red: the effective group). Red represents the higher expression, and green represents the lower expression; (B) volcano plot showing clusters of circRNAs differentially expressed between the effective group and ineffective groups, with 989 and 388 up- and down-regulated circRNAs, respectively (fold change ≥1.5 and P<0.05). The vertical gray lines correspond to 1.5-fold up- and down-regulation and the horizontal gray line represents a P value of 0.05. Red and green points in the plot represent the significantly differentially expressed circRNAs; (C) significantly enriched pathways in genes regulated by differentially expressed cancer-related circRNAs were identified through the KEGG pathway enrichment analysis.