Table 1.
Marginal (individual) power obtained for each outcome, when analysing two (top), three (middle) or four (bottom) continuous outcomes using a variety of methods to control the FWER
| Pairwise correlation between outcomes | None | Bonferroni | Holm | Hochberg | Hommel | Stepdown minP |
|---|---|---|---|---|---|---|
| Two outcomes | ||||||
| 0 | 80.9 | 72.4 | 78.5 | 79.2 | 79.2 | 78.2 |
| 0.2 | 80.6 | 71.8 | 77.8 | 78.6 | 78.6 | 77.7 |
| 0.4 | 80.0 | 71.3 | 76.6 | 77.7 | 77.7 | 76.7 |
| 0.6 | 80.0 | 71.0 | 76.0 | 77.4 | 77.4 | 76.7 |
| 0.8 | 80.3 | 71.3 | 75.6 | 77.4 | 77.4 | 77.2 |
| Three outcomes | ||||||
| 0 | 80.2 | 65.9 | 75.2 | 76.7 | 76.8 | 75.5 |
| 0.2 | 80.5 | 66.4 | 75.0 | 76.6 | 76.7 | 75.3 |
| 0.4 | 80.2 | 65.7 | 73.8 | 75.4 | 75.6 | 73.2 |
| 0.6 | 80.0 | 65.7 | 73.3 | 75.0 | 75.2 | 73.8 |
| 0.8 | 80.0 | 65.9 | 72.2 | 74.6 | 74.8 | 76.1 |
| Four outcomes | ||||||
| 0 | 80.5 | 62.3 | 73.2 | 75.0 | 75.2 | 72.7 |
| 0.2 | 80.4 | 62.3 | 72.6 | 74.4 | 74.8 | 72.2 |
| 0.4 | 80.6 | 62.4 | 72.1 | 74.1 | 74.4 | 72.2 |
| 0.6 | 80.3 | 62.0 | 70.7 | 73.1 | 73.5 | 72.3 |
| 0.8 | 80.3 | 61.9 | 69.7 | 73.2 | 73.6 | 73.5 |
D/AP method was not examined due to the poor performance observed when exploring FWER
There was no missing data in any of the outcomes. The tables display various degrees of correlation between the outcomes, ranging from no correlation (ρ = 0.0) to strong correlation (ρ = 0.8)