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. 2019 Jun 18;9(6):e026711. doi: 10.1136/bmjopen-2018-026711

Table 2.

Schedule of enrolment, interventions and outcome assessments

Study period
Screening and eligibility/allocation Post-allocation Close-out
Time-point T0 T1 T2 T3
(D=day, W=week) D2 W2 W4 W8
Eligibility screening ✓
 Medical history review ✓
 Physical and VNG examination ✓
Informed consent ✓
Demographic and clinical characteristics ✓
Allocation ✓
Interventions
 VR (Group A) graphic file with name bmjopen-2018-026711ilf03.jpg
 Betahistine (Group B) graphic file with name bmjopen-2018-026711ilf01.jpg
 VR plus betahistine (Group C) graphic file with name bmjopen-2018-026711ilf02.jpg
Assessments of outcome variables
 VAP ✓ ✓ ✓ ✓
 CDP ✓ ✓/* ✓/*
 DHI ✓ ✓ ✓ ✓
 oVEMP ✓ ✓/* ✓/*
 cVEMP ✓ ✓/* ✓/*
 Symptom duration ✓ ✓ ✓

*Test is only repeated when the previous exam indicates abnormality.

CDP, computerised dynamic posturography; cVEMP, cervical vestibular-evoked myogenic potential; DHI, Dizziness Handicap Inventory; oVEMP, ocular vestibular-evoked myogenic potential; VAP, Vestibular Activities and Participation; VNG, videonystagmography; VR, vestibular rehabilitation.