Table 1.
Phase | Measurements |
Baseline survey: 2008 (WSAS I); 2016 (WSAS I and WSAS II) |
Self-completed questionnaire only:
Self-reported asthma, allergy, respiratory symptoms, medication use Self-reported socio-economic status; smoking habits; and airborne, occupational and environmental exposures |
First clinical follow-up: 2009–2012; 2018-ongoing |
Structured clinical interview and self-administered questionnaire:
Questions about asthma, allergy, respiratory symptoms, medication use Other questions about smoking habits, food intolerance, self-efficacy; personality traits; beliefs about asthma medications depression and anxiety and quality of life Anthropometric measures: height and weight measurements Clinical examinations: Haemoglobin saturation; blood pressure; blood samples; nasal lavage; skin prick test; specific immunoglobulin E; differential cell counts in blood; component resolved diagnostics; body fat; muscle mass; metabolic age (impedance); hand strength with grip pit; forced impulse oscillometry; forced oscillometry technique (small airways); diffusion capacity; functional residual capacity and total lung capacity; dynamic spirometry (Jaeger’s MasterScope, methacholine test); exhaled nitric oxide. Other clinical measurements* are: induced sputum, nasal biopsies, nasal swabs for virus determination and bronchoschopy including bronchial biopsies, bronchial lavage and bronchial brushings. |
Ongoing/planned: 2019- | Proteomics (conventional proteomics and mass cytometry; CyTOF)* Genomics* Transcriptomics (ie, RNA and microRNA analysis)* Linkage to national healthcare registers |
*Carried out in a subpopulation of those that were clinically examined.