. 2019 May 24;160(7):1613–1630. doi: 10.1210/en.2019-00287

Table 1.

Longitudinal Impacts of Perinatal Phthalate Exposures on Body Composition

Exposure Group	Body Fat Percentage						Lean Mass Percentage
	2 mo		8 mo		Longitudinal Analysis		2 mo		8 mo		Longitudinal Analysis
	n	Mean ± SE	n	Mean ± SE	β	P Value	n	Mean ± SE	n	Mean ± SE	β	P Value
Females
Control	11	13.05 ± 0.62	13	32.94 ± 1.92	Ref.	Ref.	11	67.98 ± 0.48	13	52.76 ± 1.67	Ref.	Ref.
DEHP	9	15.14 ± 0.81	11	36.52 ± 1.24	3.63	δ 0.01^a	9	66.53 ± 0.47	11	49.66 ± 1.06	−2.98	δ 0.01^a
DBP	8	14.58 ± 0.95	9	37.09 ± 1.70	2.62	0.08^b	8	67.17 ± 0.63	9	49.26 ± 1.37	−1.96	0.09^b
DINP	10	15.10 ± 0.80	12	34.87 ± 1.57	2.82	0.05^c	10	66.20 ± 0.78	12	51.06 ± 1.34	−2.47	0.03^c
DEHP+DINP	11	13.61 ± 0.61	13	34.99 ± 1.93	1.68	0.21	11	67.77 ± 0.59	13	50.95 ± 1.58	−1.36	0.20
DEHP+DINP+DBP	10	14.43 ± 0.55	12	32.00 ± 1.90	0.76	0.58	10	67.55 ± 0.49	12	53.41 ± 1.55	−0.04	0.74
Males
Control	10	12.18 ± 0.61	12	27.39 ± 0.95	Ref.	Ref.	10	69.37 ± 0.48	12	57.10 ± 0.81	Ref.	Ref.
DEHP	8	13.51 ± 1.40	10	29.39 ± 1.07	1.62	0.12	8	69.15 ± 1.14	10	55.28 ± 0.87	−1.06	0.23
DBP	9	12.53 ± 0.71	10	27.34 ± 1.00	−0.19	0.86	9	69.70 ± 0.65	10	56.81 ± 0.88	0.26	0.77
DINP	9	13.68 ± 0.95	9	26.77 ± 0.85	0.51	0.63	9	68.19 ± 0.90	9	57.58 ± 0.78	−0.47	0.60
DEHP+DINP	10	12.82 ± 0.57	12	26.56 ± 1.26	0.006	1.00	10	69.29 ± 0.52	12	57.72 ± 1.15	0.1	0.91
DEHP+DINP+DBP	9	12.56 ± 0.54	11	27.79 ± 0.80	0.17	0.87	9	69.26 ± 0.66	11	56.59 ± 0.70	−0.11	0.91

β Coefficients and P values are from LME models of longitudinal metabolic parameters comparing each exposure group to controls. Body composition data were obtained at 2 and 8 mo of age. Models controlled for the presence of gross liver masses at necropsy. Body fat percentage and lean mass percentage are expressed as percentage of body weight. Each exposure group was compared with controls, resulting in five comparisons per model; to account for multiple comparisons, P value cutoffs of 0.05 for significant and 0.10 for borderline significant are adjusted to 0.01 and 0.02, respectively. Comparisons that remained statistically significant after accounting for multiple comparisons are denoted with δ.

^{^a}

P ≤ 0.01, compared with controls.

^{^b}

P ≤ 0.10, compared with controls.

^{^c}

P ≤ 0.05, compared with controls.