Table 4.

Predictive value of the American Heart Association (AHA) recommendations

Discharge outcome
	TP, N	FP, N	TN, N	FN, N	p	FPR, % (95% CI)	Sensitivity, % (95% CI)
Bilaterally absent pupillary light reflex, day 3	51	0	24	130	<0.001	0 (0–14)	28 (22–35)
Bilaterally absent pupillary light reflex, day 4	43	0	24	121	0.002	0 (0–14)	26 (20–33)
Myoclonic status epilepticus at ≤72h	60	0	24	142	<0.001	0 (0–14)	30 (24–36)
Burst suppression	24	0	16	157	0.23	0(0–19)	13 (9–19)
Unreactive EEG to stimuli	92	0	9	48	<0.001	0 (0–30)	66 (58–73)
Status epilepticus	12	0	24	190	0.62	0 (0–14)	6 (3–10)
Absent N20s on days 1–3	10	0	0	5	>0.99	0 (0–100)	67 (42–85)
NSE >33.0 mcg/L	22	0	3	9	0.04	0 (0–56)	71(53–84)
NSE >78.9 mcg/L	15	0	3	16	0.24	0 (0–56)	48 (32–65)
Reduced GWR on head CT at ≤24h	22	0	19	139	0.13	0(0–17)	14 (9–20)
Diffuse hypoxic-ischemic injury on brain MRI, days 2–6	60	1	7	28	0.003	12 (1–47)	68 (58–77)
6 month outcome
	TP, N	FP, N	TN, N	FN, N	p	FPR, % (95% CI)	Sensitivity, % (95% CI)
Bilaterally absent pupillary light reflex, day 3	49	2	31	124	0.007	6 (1–20)	28 (22–35)
Bilaterally absent pupillary light reflex, day 4	42	1	32	114	0.002	3 (0–15)	27 (21–34)
Myoclonic status epilepticus at ≤72h	59	1	32	134	<0.001	3 (0–15)	31(25–37)
Burst suppression	24	0	24	149	0.05	0 (0–14)	14 (10–20)
Unreactive EEG to stimuli	92	0	17	40	<0.001	0 (0–18)	70 (61–77)
Status epilepticus	12	0	33	181	0.22	0 (0–10)	6 (4–11)
Absent N20s on days 1–3	10	0	0	5	>0.99	0 (0–100)	67 (42–85)
NSE >33.0 mcg/L	21	1	3	9	0.12	25 (1–70)	70 (52–83)
NSE >78.9 mcg/L	15	0	4	15	0.11	0 (0–49)	50 (33–67)
Reduced GWR on head CT at ≤24h	22	0	26	132	0.05	0 (0–13)	14 (10–21)
Diffuse hypoxic-ischemic injury on brain MRI, days 2–6	59	2	15	20	<0.001	12 (2–34)	75 (64–83)

Abbreviations: TP = true positive; FP = false positive; TN = true negative; FN = false negative; FPR = false positive rate; NSE = neuron specific enolase; GWR = grey-white matter ratio

P values are calculated for contingency tables.