Figure 2.

Correlation between predicted and experimental values for mutation-induced folding stability and binding affinity changes. (A, B) Folding stability changes upon mutation, $\Delta \Delta G_{stability}^{WT\to mut},$ for monomer proteins predicted by EvoEF (A) and FoldX (B) versus the experimental data for 1,994 test proteins. (C, D) Binding affinity changes upon mutation in the interface of protein-protein complexes, $\Delta \Delta G_{binding}^{WT\to mut}$, predicted by EvoEF (C) and FoldX (D) versus the experimental data for 1,102 test proteins.