Table 1.

List of features included in the SVM

Wild-type residue (one feature element for each of the 20 amino acids)

Mutant residue (one feature element for each of the 20 amino acids)

Wild-type residue type (from aliphatic, acidic, basic, aromatic, and polar)

Mutant residue type (from aliphatic, acidic, basic, aromatic, and polar)

Difference between wild-type and mutant residues for following: (1) Kyte–Doolittle hydropathy; (2) free energy of solvation; (3) normalized van der Waals radius; (4) polarity difference; (5) charge difference

Whether the mutation falls in one of the following kinase subdomains: (1) nucleotide-binding loop; (2) αC-helix; (3) catalytic loop; (4) activation loop