Table 3.

BRAF mutations: comparison of MD, SVM, SIFT, and PolyPhen2, against experiments

Mutation, BRAF	MD prediction	SVM prediction	SIFT	PolyPhen2	Experimental
G596R	1	0	1	1	0
V600R	1	1	1	1	1
V600E	1	1	1	1	1
L597V	1	1	1	1	1
D594V	0	0	1	1	0
F595L	1	0	1	1	1
I463S	1	1	1	1	1
K601E	1	1	0	1	1
G464E	0	0	1	1	1
R462I	0	1	0	0	1
G466V	0	1	1	1	0
N581S	0	1	1	1	1
V600K	0	1	1	1	1
G466A	0	1	1	1	1
G464V	0	1	1	1	1
T599I	0	0	1	1	1
G469E	0	0	1	1	0
G466E	0	0	1	1	0
V600D	0	1	1	1	1
G469V	1	1	1	1	1
TPR	0.4666	0.8	0.8666	0.9333
FPR	0.2	0.2	1	1
BACC	0.6333	0.8	0.4333	0.4666