Table 4.

ALK mutations: comparison of MD, SVM, SIFT, and PolyPhen2, against experiments

Mutation, ALK	MD prediction	SVM prediction	SIFT	PolyPhen2	Experimental
F1174L	1	1	1	1	1
F1245V	1	1	1	1	1
F1245C	1	1	0	1	1
I1170N	0	1	1	1	1
I1170S	1	1	1	1	1
I1171N	1	1	1	1	1
Y1278S	0	1	1	1	1
R1192P	0	1	1	1	1
M1166R	1	1	0	1	1
R1275Q	0	1	1	1	1
T1151M	1	1	0	1	1
L1196M	1	1	0	1	1
G1128A	1	1	1	1	1
I1183T	0	1	1	1	0
L1204F	1	0	1	1	1
G1286R	0	0	0	1	0
A1200V	0	0	1	1	0
D1349H	0	1	1	1	0
T1343I	0	0	1	1	0
R1231Q	0	1	0	0	0
I1250T	0	0	1	1	0
G1286A	0	0	1	1	0
L1204F	1	0	1	1	0
D1270G	0	0	1	1	0
TPR	0.7143	0.9286	0.7143	1
FPR	0.1	0.3	0.8	0.9
BACC	0.8071	0.8143	0.4571	0.55