Table 2.
Association between the BET1L and H19 polymorphisms and IA risk.
| Polymorphisms | Controls, n = 588 (%) | Patients, n = 542 (%) | Adjusted OR (95% CI)† | P value |
|---|---|---|---|---|
| BET1L rs2280543 | ||||
| CC | 455 (77.4) | 380 (70.1) | 1.00 | |
| CT | 123 (20.9) | 147 (27.1) | 1.43 (1.08-1.90) | 0.01 |
| CT/TT | 133 (22.6) | 162 (29.9) | 1.48 (1.12-1.94) | 0.005 |
| Additive model | 1.40 (1.11-1.78) | 0.005 | ||
| C allele | 1033 (87.8) | 907 (83.7) | 1.00 | |
| T allele | 143 (12.2) | 177 (16.3) | 1.44 (1.13-1.83) | 0.003 |
| H19 rs217727 | ||||
| CC | 238 (40.5) | 182 (33.6) | 1.00 | |
| CT | 259 (44.0) | 230 (42.4) | 1.14 (0.87-1.49) | 0.36 |
| TT | 91 (15.5) | 130 (24.0) | 1.90 (1.35-2.67) | <0.001 |
| CT/TT | 350 (59.5) | 360 (66.4) | 1.33 (1.03-1.71) | 0.03 |
| Additive model | 1.33 (1.13-1.56) | <0.001 | ||
| C allele | 735 (62.5) | 594 (54.8) | 1.00 | |
| T allele | 441 (37.5) | 490 (45.2) | 1.38 (1.16-1.64) | <0.001 |
| H19 rs2839698 | ||||
| CC | 318 (54.1) | 312 (57.6) | 1.00 | |
| CT | 221 (37.6) | 194 (35.8) | 0.90 (0.70-1.17) | 0.44 |
| TT | 49 (8.3) | 36 (6.6) | 0.80 (0.50-1.27) | 0.33 |
| CT/TT | 270 (45.9) | 230 (42.4) | 0.88 (0.69-1.13) | 0.32 |
| Additive model | 0.88 (0.73-1.06) | 0.18 | ||
| C allele | 857 (72.9) | 818 (75.5) | 1.00 | |
| T allele | 319 (27.1) | 266 (24.5) | 0.89 (0.74-1.08) | 0.25 |
| H19 rs2735971 | ||||
| GG | 413 (70.2) | 382 (70.5) | 1.00 | |
| AG | 153 (26.0) | 130 (24.0) | 0.86 (0.65-1.14) | 0.30 |
| AA | 22 (3.7) | 30 (5.5) | 1.54 (0.87-2.74) | 0.14 |
| AG/AA | 175 (29.8) | 160 (29.5) | 0.95 (0.73-1.24) | 0.70 |
| Additive model | 1.04 (0.85-1.28) | 0.68 | ||
| G allele | 979 (83.2) | 894 (82.5) | 1.00 | |
| A allele | 197 (16.8) | 190 (17.5) | 1.04 (0.83-1.30) | 0.74 |
IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval. †Adjusted by age, gender, and familial history of IA.