Table 5.
Combined analyses of the BET1L and H19 polymorphisms with IA risk.
| Combined genotypes | Controls (%) | IA (%) | OR (95% CI) | P value |
|---|---|---|---|---|
| BET1L rs2280543-H19 rs217727 | ||||
| rs2280543 CC-rs217727 CC | 238 (40.5) | 121 (22.3) | 1.00 | |
| rs2280543 CC-rs217727 CT/TT | 217 (36.9) | 259 (47.8) | 2.35 (1.77-3.12) | <0.001 |
| rs2280543 CT/TT-rs217727 CC | — | 61 (11.3) | — | — |
| rs2280543 CT/TT-rs217727 CT/TT | 133 (22.6) | 101 (18.6) | 1.49 (1.06-2.10) | 0.02 |
| BET1L rs2280543-H19 rs2839698 | ||||
| rs2280543 CC-rs2839698 CC | 237 (40.3) | 219 (40.4) | 1.00 | |
| rs2280543 CC-rs2839698 CT/TT | 218 (37.1) | 161 (29.7) | 0.80 (0.61-1.05) | 0.11 |
| rs2280543 CT/TT-rs2839698 CC | 81 (13.8) | 93 (17.2) | 1.24 (0.88-1.76) | 0.22 |
| rs2280543 CT/TT-rs2839698 CT/TT | 52 (8.8) | 69 (12.7) | 1.44 (0.96-2.15) | 0.08 |
| BET1L rs2280543-H19 rs2735971 | ||||
| rs2280543 CC-rs2735971 GG | 325 (55.3) | 265 (48.9) | 1.00 | |
| rs2280543 CC-rs2735971 AG/AA | 130 (22.1) | 115 (21.2) | 1.09 (0.81-1.46) | 0.59 |
| rs2280543 CT/TT-rs2735971 GG | 88 (15.0) | 117 (21.6) | 1.63 (1.18-2.25) | 0.003 |
| rs2280543 CT/TT-rs2735971 AG/AA | 45 (7.7) | 45 (8.3) | 1.23 (0.79-1.91) | 0.37 |
| H19 rs217727-H19 rs2839698 | ||||
| rs217727 CC-rs2839698 CC | 128 (21.8) | 105 (19.4) | 1.00 | |
| rs217727 CC-rs2839698 CT/TT | 110 (18.7) | 77 (14.2) | 0.85 (0.58-1.26) | 0.42 |
| rs217727 CT/TT-rs2839698 CC | 190 (32.3) | 207 (38.2) | 1.33 (0.96-1.84) | 0.09 |
| rs217727 CT/TT-rs2839698 CT/TT | 160 (27.2) | 153 (28.2) | 1.17 (0.83-1.64) | 0.38 |
| H19 rs217727-H19 rs2735971 | ||||
| rs217727 CC-rs2735971 GG | 175 (29.8) | 128 (23.6) | 1.00 | |
| rs217727 CC-rs2735971 AG/AA | 63 (10.7) | 54 (10.0) | 1.17 (0.76-1.80) | 0.47 |
| rs217727 CT/TT-rs2735971 GG | 238 (40.5) | 254 (46.9) | 1.46 (1.09-1.95) | 0.01 |
| rs217727 CT/TT-rs2735971 AG/GG | 112 (19.0) | 106 (19.6) | 1.29 (0.91-1.84) | 0.15 |
IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval.