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. 2019 Jun 2;2019:8765954. doi: 10.1155/2019/8765954

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Copyright © 2019 Hassan Farghali et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of quercetin and SRT1720 pretreatments on (a) SIRT1 and (b) HO-1 protein expressions in lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized (D-GalN/LPS) rats after 24 hours. Beta-actin was used as an endogenous control. CO: negative control, vehicle only; Q: quercetin 50 mg/kg; SRT1720: SRT1720 5 mg/kg; D-GalN/LPS: D-galactosamine 400 mg/kg + lipopolysaccharide 10 μg/kg; Q + D-GalN/LPS: combination of Q and D-GalN/LPS; SRT1720 + D-GalN/LPS: combination of SRT1720 and D-GalN/LPS. ∗ indicates significant values (P ≤ 0.05) compared to the negative control group (vehicle only); # indicates significant values (P ≤ 0.05) compared to the D-GalN/LPS group. The results are expressed as means ± SEM, n = 5 (courtesy of Physiological Research, reference [98]).