Table 2.
Disease-free survival univariable and multivariable Cox regression analysis in gastric cancer.
| Number of events | Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Laurén classification | |||||||
| Intestinal | 28 | 1 | 1 | ||||
| Diffuse | 7 | 1.17 | 0.51-2.68 | 0.71 | 0.71 | 0.31-1.66 | 0.44 |
| Mixed | 23 | 1.78 | 1.03-3.10 | 0.04∗ | 1.08 | 0.58-1.99 | 0.81 |
| Growth pattern | |||||||
| Infiltrative | 62 | 1 | 1 | ||||
| Expansive | 10 | 0.45 | 0.23-0.88 | 0.02∗ | 0.52 | 0.20-1.37 | 0.19 |
| TNM | |||||||
| I | 5 | 1 | 1 | ||||
| II | 26 | 8.10 | 3.11-21.12 | <0.01∗ | 9.19 | 2.64-32.01 | <0.01∗ |
| III | 42 | 24.91 | 9.81-63.30 | <0.01∗ | 23.40 | 6.74-81-23 | <0.01∗ |
| Resection margins | |||||||
| R0 | 67 | 1 | 1 | ||||
| R1/R2 | 5 | 14.33 | 5.38-38.19 | <0.01∗ | 7.83 | 2.54-25.02 | <0.01∗ |
| Vascular invasion | |||||||
| No | 24 | 1 | 1 | ||||
| Yes | 49 | 2.28 | 1.40-3.72 | <0.01∗ | 0.90 | 0.49-1.65 | 0.73 |
| Perineural invasion | |||||||
| No | 26 | 1 | 1 | ||||
| Yes | 47 | 3.10 | 1.92-5.02 | <0.01∗ | 0.64 | 0.35-1.17 | 0.15 |
| SOX9 | |||||||
| No | 21 | 1 | 1 | ||||
| Yes | 52 | 0.58 | 0.35-0.97 | 0.04∗ | 0.90 | 0.50-1.62 | 0.72 |
Notes. P values (statistical significance threshold < 0.05) were obtained using univariable and multivariable Cox proportional hazards regression analysis (Wald). ∗Comparisons with P < 0.05. HR = hazard ratio; CI = confidence interval.