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. 2019 Jun 2;2019:6173685. doi: 10.1155/2019/6173685

Figure 1.

Figure 1

Pretreatment of ZYZ-803 preserves the left ventricular function and palliates the myocardial infarction scale. Mice were suffered from 24-hour ligation of the left anterior descending coronary artery after 5-day ZYZ-803 preconditioning. (a) Representative echocardiographs from transthoracic two-dimensionally directed M-mode echocardiography. (b–e) Statistical data of (b) left ventricular ejection fraction (LVEF (%)), (c) left ventricular fractional shortening (LVFS (%)), (d) left ventricular systolic diameter (LVSD (mm)), and (e) left ventricular systolic volume (LVSV (μl)), assessed by echocardiography (n = 6 mice in each group). Data are mean ± SEM, one-way ANOVA. # P < 0.001 versus sham group; ∗∗ P < 0.01 and ∗ P < 0.05 compared with the model group. (f) Representative photographs for IS and AAR in the heart by TTC and Evans blue dye from each group. Scale bar (red): 1 mm. Quantitative data of (g) AAR/LV and (h) IS/AAR. AAR: area at risk; IS: infarct size; LV: left ventricle (n = 6 mice per group). Compared to the model group, ∗∗ P < 0.01 and ∗ P < 0.05. Data are mean ± SEM, one-way ANOVA.