Figure 2.

ZYZ-803 decreases the level of serum biomarkers for myocardial necrosis and improves the compromised cardiac compliance. (a, b) Both serum LDH and cTnI were decreased by ZYZ-803, n = 6 mice per group; compared to the model group, ^∗∗ P < 0.01 and ^∗∗∗ P < 0.001. Data are mean ± SEM, one-way ANOVA. (c) Hematoxylin and eosin staining of heart tissue sections from experimental animals to evaluate the severity of histopathologic changes after AMI. (d) Sirius red dye for evaluation of collagen deposition after mouse AMI. Red bars: 2.5 mm; black bars: 100 μm.