Figure 7.
Schematic diagram for the new mechanism of ZYZ-803 in ER stress-related cardiac necroptosis. Aberrant ERS could be evoked during AMI and by its typical agonist tunicamycin in cardiomyocytes, which potentially induces myocardial necroptosis through the RIP3-CaMKII pathway. ZYZ-803, a dual donor for gasotransmitters H2S and NO, could downregulate this ERS-related necroptosis at upstream of RIP3-CaMKII signaling through H2S and NO balance and finally protects the heart from acute myocardial ischemia injury.