Table 1.
Cox Proportional-Hazards Association Analysis of LIMS1 Collision Genotype with Allograft Rejection in a Time-to-Event Analysis, According to Cohort.
| Cohort | Population | Minimally Adjusted Model* | Fully Adjusted Model† | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | ||
| Columbia discovery cohort | 705 Recipients | 1.84 (1.35–2.50) | 9.8×10−5 | 1.76 (1.29–2.40) | 3.8×10−4 |
| Belfast replication cohort | 387 Donor–recipient pairs | 1.70 (1.03–2.82) | 4.0×10−2 | 1.77 (1.06–2.93) | 2.8×10−2 |
| TransplantLines replication cohort | 833 Donor–recipient pairs | 1.53 (1.13–2.09) | 6.6×10−3 | 1.58 (1.14–2.19) | 5.7×10−3 |
| Torino replication cohort | 784 Donor–recipient pairs | 1.49 (1.02–2.16) | 3.9×10−2 | 1.53 (1.05–2.23) | 2.6×10−2 |
| All replication cohorts | 2004 Donor–recipient pairs | 1.55 (1.25–1.93) | 6.5×10−5 | 1.58 (1.27–1.97) | 5.1×10−5 |
| All cohorts | 2709 Transplants | 1.63 (1.37–1.95) | 4.7×10−8 | 1.63 (1.36–1.95) | 9.4×10−8 |
*
The analysis was adjusted for cohort only (if applicable).
†
The analysis was adjusted for recipient’s age, sex, race, ethnic group, HLA-mismatch status, and cohort (if applicable).