Table 1 |.

Estimated FDR and false positive rate for the 90th, 95th, and 99th percentiles

Minimum CCR percentile	FDR	False positive rate
90	0.077	0.057
95	0.055	0.029
99	0.028	0.006

A total of 3,400 DNMs from neurodevelopmental disorder probands are treated as true positives; 1,269 DNMs from unaffected siblings of autism probands represent true negatives, and when overlapping a CCR, they are treated as false positives. FDR is calculated as false positives/(false positives + true positives) and false positive rate as false positives/(false positives + true negatives).