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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Protein J. 2019 Jun;38(3):274–288. doi: 10.1007/s10930-019-09826-7

Figure 2.

Figure 2.

Synthesis of native and foreign lipids in E. coli. The enzymes with their respective genes named catalyze the following steps for synthesis of native phospholipids noted in blue: 1. CDP-diacylglycerol synthase; 2. phosphatidylserine synthase; 3. phosphatidylserine decarboxylase; 4. phosphatidylglycerophosphate synthase; 5. phosphatidylglycerophosphate phosphatases encoded by three genes; 6. cardiolipin synthases encoded by 3 genes; 7. phosphatidylglycerol:pre-membrane derived oligosaccharide (MDO) sn-glycerol-1-P transferase; 8. diacylglycerol kinase. The enzymes with their respective genes named and their source catalyze the following steps for synthesis of phospholipids foreign to E. coli noted in red: 9. phosphatidylcholine synthase (Legionella pneumophila [21,22]); 10. phosphatidylinositol synthase (Saccharomyces cerevisiae [23]); 11. glucosyl diacylglycerol synthase (Acholeplasma laidlawii [24]); 12. diglucosyl diacylglycerol synthase (Acholeplasma laidlawii [25]); 13. lysyl t-RNA:phosphatidylglycerol lysine transferase (Staphylococcus aureus [26]). Figure (modified) and legend reprinted by permission from Springer Nature: [27] Copyright 2018.