Domain architecture of mannosidases: ER Man1, EDEM1, EDEM2, EDEM3, and endomannosidase. The signal sequences (black), predicted transmembrane domains (grey), the mannosidase domains (orange), and putative catalytic residues (stars) are designated. Endomannosidase possesses a predicted non-cleavable signal sequence, as shown by a half black and half grey box.