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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Protein J. 2019 Jun;38(3):317–329. doi: 10.1007/s10930-019-09831-w

Fig. 5. Redox reactions catalyzed by PDI family members.

Fig. 5

PDI, or members of the protein disulfide isomerase family (PDIf), can oxidize, reduce and isomerize disulfide bonds of substrates. In all cases, a transient intermolecular disulfide bond is formed between PDIf and the substrate (not pictured). While the various PDIf members have varying numbers of catalytic domains, a single catalytic site of PDIf is displayed for simplification.