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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bone. 2019 May 16;125:151–159. doi: 10.1016/j.bone.2019.05.018

Figure 1. Schematic of experimental procedure.

Figure 1.

(A) MSC spheroids were preconditioned in either CoCl2 or ambient conditions for 72 h and then maintained in serum-containing growth media for 24 h. Conditioned media was then collected as spheroid-conditioned media (SPH). In some cases, SPH was incubated with L6 myoblasts for 24 h, yielding spheroid-myoblast conditioned media (SPH-MYO). (B) Schematic of experiments to investigate the therapeutic potential of conditioned media in vivo.