TABLE 1.
Characteristics of HRIs (n = 65)
| No. of cases | Percent of total | |
|---|---|---|
| HRI with mutation | 40 | 61.54 |
| BRCA1 | 6 | |
| BRCA2 | 19 | |
| PALB2 | 3 | |
| ATM | 3 | |
| CDKN2A | 1 | |
| BRCA2+ATM | 1* | |
| Lynch syndrome | 5 | |
| PJS | 2 | |
| vHRIs | 44 | 67.69 |
| vHRIs with FH | 24 | |
| 2+ FDRs | 12 | |
| 1 FDR and 1+ non-FDR | 12 | |
| vHRIs with mutation | 20 | |
| BRCA2 and 1+ FDR | 12* | |
| PALB2 and 1+ FDR | 1 | |
| CDKN2A and 1+ FDR | 1 | |
| Lynch syndrome and 1+ FDR | 4 | |
| PJS | 2 | |
| mHRIs | 21 | 32.31 |
| mHRIs with FH | 1 | |
| 0 FDR and 3+ non-FDRs | 1 | |
| mHRIs with mutation | 20 | |
| BRCA1 and 1+ non-FDR | 3 | |
| BRCA1 with no FH | 3 | |
| BRCA2 and 1+ non-FDR | 5 | |
| BRCA2 with no FH | 3 | |
| PALB2 with any/no FH | 2 | |
| CDKN2A with any/no FH | 0 | |
| Lynch syndrome with any/no FH | 1 | |
| ATM with any/no FH | 3 |
HRI, High-risk individual; FH, family history; vHRI, HRIs who meet the Cancer of the Pancreas Screening consortium criteria; mHRI, HRIs who do not meet the Cancer of the Pancreas Screening consortium criteria; FDR, first-degree relative.
*
One vHRI had ATM and BRCA2 mutations