. Author manuscript; available in PMC: 2019 Jun 24.

Published in final edited form as: Gastrointest Endosc. 2018 Aug 24;89(4):842–851.e1. doi: 10.1016/j.gie.2018.08.029

TABLE 6.

Prior studies investigating chronic pancreatitis changes on EUS in HRIs

Study	HRI characteristics	Screening	No. of HRIs	CP criteria examined	CP results in HRIs	CP results in HRIs
Canto et al 2004²⁵	FH; PJS	EUS, ERCP, CT	38	3+ CP changes	17/38 (45%)
Canto et al 2006²²	FH; PJS; BRCA2	EUS, ERCP, CT	78	3+ CP changes	47/78 (60%)	23/138 (17%)
Langer et al 2009¹⁴	FH; BRCA2	EUS, MRI	76	3+ CP changes	17/76 (22%)
				5+ CP changes	8/76 (11%)
Poley et al 2009¹⁵	FH; BRCA1/2; LS; CDKN2A	EUS	44	1+ CP changes	3/10 (30%)^*
Verna et al 2010⁶	FH; PALB2	EUS, MRI	31	3+ CP changes	6/31 (19%)
				5+ CP changes	2/31 (6%)
Sud et al 2014¹⁷	FH; BRCA1/2; CDKN2A; LS	EUS	16	1+ CP changes	0/16 (0%)
Harinck et al 2016¹³	FH; PJS; BRCA1/2; CDKN2A	EUS, MRI	139	1+ CP changes	20/139 (14%)
Mocci et al 2015¹²	FH; PJS; LS; CDKN2A; BRCA1/2	EUS → MRI	38	1+ parenchymal CP changes	16/38 (42%)
Mizrahi et al 2017¹⁰	BRCA2	EUS	37	Rosemont consistent with CP	5/37 (14%)	1/92 (1%)
				Rosemont suggestive of CP	6/37 (16%)	2/92 (2%)
				Lobularity	7/37 (18%)	3/92 (3%)
				Hyperechoic strands	14/37 (37%)	6/92 (7%)
DaVee et al 2018¹¹	BRCA1/2; p53; PJS; LS; ATM; APC	EUS, MRI, CT	64	Hyperechoic strands and foci	9/64 (14%)
				Mild MPD dilation	2/64 (3%)

HRI, High-risk individual; CP, chronic pancreatitis; FH, family history; PJS, Peutz-Jeghers syndrome; MRI, magnetic resonance imaging; LS, Lynch syndrome; MPD, main pancreatic duct.

In Poley et al, only looked at CP changes in 10 patients with pathologic findings on EUS.