Table 1.
Experimental design
| Group | n (males) | DEN in PBS (mg/kg) | Volume (mL/kg) | CCl4 in Olive Oil (mL/kg) | Volume (mL/kg) | LV-FAH (TU)a | TU/kgb | n Necropsy day 106 |
|---|---|---|---|---|---|---|---|---|
| 1 | 21 | 0 | 15 | 0 | 15 | – | 0 | 16 |
| 2 | 22 | 1.0 | 15 | 0.2 | 15 | – | 0 | 20 |
| 3 | 21 | 0 | 15 | 0 | 15 | 109 | 6.3 × 1010 | 20 |
| 4 | 22 | 1.0 | 15 | 0.2 | 15 | 109 | 6.9 × 1010 | 21 |
a
“–” Indicates treatment not administered to this group.
b
Based on mean group starting body weights of 15.8 g (group 3) and 14.4 g (group 4).
FAH, human fumarylacetoacetate hydrolase; LV, lentiviral vector; TU, transducing units.