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. 2018 Nov 5;38(1):e99506. doi: 10.15252/embj.201899506

Figure EV1. Loss of Vgll4 in tumor cells does not affect cell proliferation, but inhibits tumor growth in syngeneic mouse model.

Figure EV1

  • A, B
    shVgll4 LLC (A) and MB49 (B) cells grew similar as control cells in regular cell cultures using CCK8 assay. n = 3, mean ± SEM.
  • C
    The gross appearance of the primary tumors of control or shVgll4 LLC from C57BL/6 mice.
  • D
    The gross appearance of the primary tumors of control or shVgll4 LLC from nude mice. VGLL4 protein expression levels in the tumor lysates from nude mice were analyzed by Western blot and shown in the right panel.
  • E
    The gross appearance of the primary tumors of control or shVgll4 MB49 from C57BL/6 mice.
  • F
    The gross appearance of the primary tumors of control or shVgll4 MB49 from nude mice. VGLL4 protein expression levels in the tumor lysates from nude mice were analyzed by Western blot and shown in the right panel.
  • G
    The gross appearance of the primary shVgll4 MB49 tumors from C57BL/6 mice receiving anti‐CD4 alone, anti‐CD8 alone, or both anti‐CD4 and anti‐CD8 blocking antibodies.

Source data are available online for this figure.