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. 2019 Jan 15;30(2):219–227. doi: 10.1091/mbc.E17-10-0582

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© 2019 Stormo and Fox. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 1: — Potential cohesin regulation and impact on mitotic chromosome structure in two distinct Drosophila cell types that undergo endocycles. (A) Depiction of the outcome of two endocycles. In an induced endocycle, all sister chromatids are attached generating a diplochromosome. During a developmental endocycle, only recent sisters are attached at mitosis. (B) Two potential simplified depictions of the cohesin complex entrapping a pair of sister chromatids. (B′) DNA release by exit gate opening. (B″) DNA release by Rad21 cleavage.