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. 2019 Jan 15;30(2):219–227. doi: 10.1091/mbc.E17-10-0582

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© 2019 Stormo and Fox. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 5: — Pds5 is required for cohesin regulation during papillar endocycles. (A, B) Representative metaphase chromosome spreads of wild-type and pds5-RNAi papillar cells. Corresponding diagrams depict cohesin state. DAPI marks DNA. (C) Quantification of percentage of metaphase spreads in each class. N = 44 control and 19 pds5 RNAi cells. (D) Quantification of mean error rate in live imaging of pds5-RNAi animals (+SEM, from N = 9 cells). (E) Time lapse of papillar cell mitosis in a bynGal4 plus UAS pds5-RNAi animal. His-2av-GFP, magenta; CenpC-tomato, green; time, minutes from anaphase onset. Scale bar = 5 µm (main images), 1 µm (insets). (F) Proposed model of cohesin regulation and function in papillar cells during endocycles, SIRS, and the first subsequent mitosis.