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. 2019 Jan 15;30(2):169–172. doi: 10.1091/mbc.E18-05-0272

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© 2019 Örd and Loog. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 3: — Schematic diagram showing the main interactions between substrate proteins and the CDK complex that determine the phosphorylation rate and specificity. The CDK active site phosphorylates full consensus motifs (S/TPXK/R) and minimal consensus (S/TP) motifs. The phosphorylation rate of a site can be increased by two docking interactions: Cks1 can bind to phosphorylated TP sites and cyclins can interact with substrates via specific short linear motifs. In both cases, the effect of docking is dependent on the relative positioning of docking sites and phosphorylation sites along the disordered substrate.