Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 15;30(2):191–200. doi: 10.1091/mbc.E18-07-0439

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Tam et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.

PMC Copyright notice

FIGURE 5: — Tubulin stability contributes to genome maintenance in splicing mutants. (A) Western blot of relative α-tubulin protein levels. Top, TUB1; bottom, intronless TUB1. (B) Quantification of TUB1 mRNA transcript levels from exon region (left) and TUB1 intron region (right) by RT-qPCR. Asterisks show p values of ΔΔCt: ***p = 0.0002; ****p < 0.0001. (C) CTF phenotypes in TUB1 or tub1Δi strains. (D) Endogenous Chr III stability in hsh155-1 and snu114-60 with intronless TUB1 (gray bars). (C, D) Fisher’s exact test. (E) Model of defective splicing-induced genome instability in yeast. (B, C, D) Mean values with SEM are shown, n = 3.