Fig. 2.

Select mRNA levels in the lung, liver, and brain relative to unventilated controls. A–D: lung mRNA levels for the proinflammatory cytokines IL-1β (A), IL-6 (B), and monocyte chemoattractant protein-1 (MCP-1; C) decreased with budesonide and surfactant (Surf + Bud). IL-8 mRNA was not significantly different (D). E: epithelial sodium channel (ENaC) mRNA increased in the lungs with budesonide exposure. F: liver mRNA for MCP-1 was decreased by budesonide. G and H: periventricular white matter mRNA levels for IL-1β (G) and MCP-1 (H) were also decreased in the brains of budesonide animals. Individual animals (n = 6 or 7 per group) are represented. Values are means ± SE. *P < 0.05 vs. surfactant-only animals at 2, 6, or 24 h.