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α1-Adrenergic agonist dose response. A and B: changes (%Δ) in resting leg blood flow and leg vascular conductance in response to local, intra-arterial infusion of phenylephrine in control subjects and heart failure patients with reduced ejection fraction (HFrEF). *P < 0.05 vs. control; #P < 0.05 vs. preinfusion.
