Fig. 3.

Natural killer (NK) cell depletion (NKD) improves mitochondrial respiration in reduced uterine perfusion pressure (RUPP) placental mitochondria. Highly coupled mitochondria were isolated from placenta, and oxygen consumption was measured using Oxygraph-2K. State 3 respiration rate show a trend in reduction in RUPP (n = 4, P = 0.094) placental mitochondria vs. normal pregnant rats (NP; n = 6). Placental mitochondria from RUPP+NKD rats (n = 5, P = 0.0207) show significant improvement in state 3 respiration (Student’s t-test). There were no differences observed in other states of respiration. Data are presented as means ± SE. Student’s t-test was used to perform statistical analysis between 2 respective groups. #Significant compared with RUPP.