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Chronic intermittent hypoxia (CIH) and static hypoxia do not promote the growth of 5TGM1 multiple myeloma cells in vitro. Top: cells were exposed to each condition for 10 h/day and CIH cycled at 12 cycles/h (n = 3 replicates per condition). Growth of 5TGM1 cells was depressed over 4 days in 2 profiles of CIH and static hypoxia. Bottom: cell growth, calculated as area under the curve over 4 days, is depressed by CIH and static hypoxia relative to control (***P < 0.05).
